Predicting Cognitive Decline among World Trade Center Responders Using functional MRI

World Trade Center (WTC) responders experience cognitive impairment at higher rates and at earlier ages than community normative samples, with underlying plasma and structural brain markers suggestive of a neurodegenerative process. Early identification of cognitive impairment and prediction of future cognitive decline is imperative for formulating accurate treatment goals and for care planning. This study aims to measure resting state networks in WTC responders with and without cognitive impairment, and associated network patterns with current and prospective cognitive performance to inform a larger study that will aim to These results will inform a study that will aim to identify (with a larger sample) how and to what extent RS fMRI metrics can be used for predicting cognitive change in WTC responders.